Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.53 |
| ▸ | PREP | P48147 | 11/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11381314 | 0.94 | ACE (0.54) | ACEPREPDPP4DPP8DPP7 | |
| SCHEMBL20718946 | 0.87 | ACE (0.53) | ACEPREPDPP4DPP8DPP7 | |
| SCHEMBL6051964 | 0.83 | ACE (0.55) | ACEPREPDPP4DPP8DPP7 | |
| SCHEMBL11392768 | 0.83 | ACE (0.59) | ACEPREP | |
| SCHEMBL11486007 | 0.83 | ACE (0.59) | ACEPREP | |
| SCHEMBL7352024 | 0.83 | ACE (0.51) | ACEPREPDPP4DPP8 | |
| SCHEMBL9362241 | 0.83 | ACE (0.51) | ACEPREP | |
| SCHEMBL31590738 | 0.83 | ACE (0.51) | ACEPREPDPP4DPP8 | |
| SCHEMBL19084116 | 0.83 | ACE (0.55) | ACEPREPDPP4DPP8DPP7 | |
| SCHEMBL11356033 | 0.81 | ACE (0.47) | ACEPREPITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0031104-B1 | THIAZOLIDINE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-10-23 | — | — | EP | disclosed |
| US-4499102-A | HYPOTENSIVE AND ANTIDIABETIC AGENTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1985-02-12 | — | — | US | disclosed |
| EP-0031104-A1 | Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1981-07-01 | — | — | EP | disclosed |