SCHEMBL10944231

SCHEMBL10944231

CCOc1c(OC)cc(NC(C)CCCN2C(=O)c3ccccc3C2=O)c2ncccc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 2/20 0.58
HSP90AB1 P08238 2/20 0.58
CASP7 P55210 2/20 0.55
CASP6 P55212 2/20 0.55
PABPC1 P11940 1/20 0.55
KDM4E B2RXH2 3/20 0.53
NSD2 O96028 1/20 0.53
MAPT P10636 1/20 0.53
IDO1 P14902 1/20 0.43
MAOA P21397 9/20 0.42
MAOB P27338 9/20 0.42
CYP1A2 P05177 2/20 0.41
RAD52 P43351 2/20 0.41
CASP1 P29466 2/20 0.41
ABCB11 O95342 1/20 0.41
ESR1 P03372 1/20 0.41
PGR P06401 1/20 0.41
ADRB2 P07550 1/20 0.41
CHRM2 P08172 1/20 0.41
ADRB1 P08588 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10944622 0.93 HSP90AA1 (0.56) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL10949994 0.93 HSP90AA1 (0.56) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL10941487 0.92 HSP90AA1 (0.54) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL10942299 0.92 HSP90AA1 (0.54) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL10942340 0.92 HSP90AA1 (0.54) HSP90AA1HSP90AB1CASP7CASP6PABPC1
Hydrochloric Acid SCHEMBL10945887 0.88 HSP90AA1 (0.53) HSP90AA1HSP90AB1CASP7CASP6PABPC1
Hydrochloric Acid SCHEMBL10945897 0.88 HSP90AA1 (0.53) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL4726838 0.88 HSP90AA1 (0.52) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL11545426 0.87 KDM4E (0.59) HSP90AA1HSP90AB1CASP7CASP6PABPC1
SCHEMBL11546682 0.86 HSP90AA1 (0.51) HSP90AA1HSP90AB1CASP7CASP6PABPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4554279-A PLASMODICIDAL THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1985-11-19 US disclosed
US-4167638-A Process for production of 8-NHR quinolines THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1979-09-11 US disclosed