SCHEMBL10950397

SCHEMBL10950397

COc1ccc(C=CC(C)O)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.64
ALDH1A1 P00352 2/20 0.64
CYP2C9 P11712 2/20 0.64
CYP2C19 P33261 2/20 0.64
MAPT P10636 1/20 0.64
ALOX15 P16050 1/20 0.64
KDM4E B2RXH2 3/20 0.55
LMNA P02545 2/20 0.55
TP53 P04637 1/20 0.55
TSHR P16473 1/20 0.55
RELA Q04206 2/20 0.53
TRPA1 O75762 1/20 0.53
CYP1A1 P04798 3/20 0.53
CYP1B1 Q16678 3/20 0.53
CYP1A2 P05177 3/20 0.53
PTGS2 P35354 2/20 0.53
F3 P13726 2/20 0.53
ALOX12 P18054 1/20 0.53
PTGS1 P23219 1/20 0.53
ESR1 P03372 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10950395 1.00 CYP3A4 (0.64) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL7897215 0.86 CYP3A4 (0.66) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL12920192 0.86 CYP3A4 (0.66) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL7897216 0.86 CYP3A4 (0.66) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL8679933 0.85 MAPT (0.49) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL8335001 0.85 MAPT (0.49) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL8679930 0.85 MAPT (0.49) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL24434700 0.85 CYP3A4 (0.61) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL9967708 0.85 CYP3A4 (0.61) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL9416019 0.82 CYP3A4 (0.62) CYP3A4ALDH1A1CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0067086-B1 BENZOXEPINE DERIVATIVES AND THEIR SULFUR AND NITROGEN ANALOGUES, THEIR PREPARATION AND APPLICATION AS MEDICAMENTS PIERRE FABRE S.A. (FR) 1985-12-11 EP disclosed
US-4556409-A CONTROLLING SOYBEAN GROWTH EMERY INDUSTRIES INC. (US) 1985-12-03 US disclosed
US-4522749-A Process for augmenting or enhancing the aroma of a fragrance by adding a vinylcyclopropane compound NATIONAL DISTILLERS AND CHEMICAL CORPORATION (US) 1985-06-11 US disclosed
US-4418202-A HERBICIDES, PESTICIDES EMERY INDUSTRIES, INC. (US) 1983-11-29 US disclosed
US-4380656-A PESTICIDES, HERBICIDES EMERY INDUSTRIES, INC. (US) 1983-04-19 US disclosed
EP-0067086-A1 Benzoxepine derivatives and their sulfur and nitrogen analogues, their preparation and application as medicaments PIERRE FABRE S.A. (FR) 1982-12-15 EP disclosed
US-3995054-A MITICIDES ZOECON CORPORATION (US) 1976-11-30 US disclosed