Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955530 | 0.85 | EGFR (0.57) | EGFRRAB9AERBB2ALDH1A1MAPT | |
| SCHEMBL11010395 | 0.82 | CCNT1 (0.50) | EGFRTDP1KMT2ARAB9AMEN1 | |
| SCHEMBL10955745 | 0.82 | TTBK1 (0.51) | EGFRKMT2AMKNK1RAB9AMEN1 | |
| SCHEMBL10956277 | 0.82 | EGFR (0.50) | EGFRKMT2AMKNK1RAB9AMEN1 | |
| SCHEMBL10958226 | 0.81 | EGFR (0.57) | EGFRRAB9AERBB2CYP1A2CYP3A4 | |
| SCHEMBL10952199 | 0.81 | DHODH (0.59) | EGFRDHODHTTBK1 | |
| SCHEMBL10955619 | 0.80 | TDP1 (0.52) | EGFRTDP1KMT2AMKNK1RAB9A | |
| Hydrochloric Acid SCHEMBL10960314 | 0.80 | EGFR (0.55) | EGFRRAB9AERBB2CYP1A2CYP3A4 | |
| SCHEMBL10960003 | 0.79 | NPC1 (0.46) | EGFRTDP1KMT2ARAB9AMEN1 | |
| SCHEMBL10958170 | 0.79 | MAPT (0.57) | EGFRTDP1KMT2ARAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105669642-A | Revaprzan hydrochloride preparation method | 江苏天士力帝益药业有限公司 | 2016-06-15 | — | — | CN | claimed |
| CN-105669642-A | Revaprzan hydrochloride preparation method | 江苏天士力帝益药业有限公司 | 2016-06-15 | — | — | CN | disclosed |
| EP-0067630-B1 | PYRIMIDINE DERIVATIVES, A PROCESS FOR PREPARING THEM AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1985-05-08 | — | — | EP | disclosed |
| US-4450162-A | Pyrimidine derivatives and a pharmaceutical composition containing them | SANKYO COMPANY, LIMITED (JP) | 1984-05-22 | — | — | US | disclosed |
| EP-0067630-A1 | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-22 | — | — | EP | disclosed |