Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 8/20 | 0.74 |
| ▸ | CA9 | Q16790 | 7/20 | 0.74 |
| ▸ | CA2 | P00918 | 5/20 | 0.74 |
| ▸ | ELANE | P08246 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10510781 | 0.87 | CA12 (0.74) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL29463843 | 0.85 | CA12 (1.00) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL14884779 | 0.85 | CA12 (1.00) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL11711641 | 0.85 | CA12 (0.75) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL23185354 | 0.84 | CA12 (0.78) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL11876414 | 0.80 | CA12 (0.70) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL10563334 | 0.79 | CA12 (0.70) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL10908945 | 0.78 | CA12 (1.00) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL23733171 | 0.77 | CA12 (0.67) | CA12CA9CA2ELANEPOLB | |
| SCHEMBL13606228 | 0.76 | CA12 (0.73) | CA12CA9CA2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049099-B1 | SYNTHETIC METHOD AND INTERMEDIATE FOR PIROXICAM | PFIZER INC. (US) | 1985-07-17 | — | — | EP | disclosed |
| EP-0049099-A2 | Synthetic method and intermediate for piroxicam | PFIZER INC. (US) | 1982-04-07 | — | — | EP | disclosed |
| US-4289879-A | Synthetic method and intermediate for piroxicam | PFIZER INC. (US) | 1981-09-15 | — | — | US | disclosed |