Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106532 | 0.87 | POLB (0.45) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1097341 | 0.86 | POLB (0.46) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1095346 | 0.85 | POLB (0.45) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1096412 | 0.84 | POLB (0.44) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1096876 | 0.84 | USP30 (0.38) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL18306498 | 0.81 | POLB (0.41) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1096148 | 0.81 | POLB (0.52) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1095511 | 0.80 | F10 (0.55) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1095698 | 0.79 | HPGD (0.53) | POLBALDH1A1HTTSMN1; SMN2JAK2 | |
| SCHEMBL1096444 | 0.79 | POLB (0.65) | POLBALDH1A1HTTSMN1; SMN2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153670-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-10 | — | — | US | claimed |
| US-8153670-B2 | Factor Xa inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-10 | — | — | US | disclosed |