Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 4/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10971251 | 0.93 | NOX1 (0.54) | NOX1MAPTNPSR1MAPK14MAPK13 | |
| SCHEMBL10966349 | 0.88 | NOX1 (0.49) | NOX1MAPTMAPK14MAPK13MAPK12 | |
| SCHEMBL10968487 | 0.87 | MAPK14 (0.62) | PTGS1PTGS2NOX1MAPK14MAPK13 | |
| SCHEMBL10968021 | 0.87 | NOX1 (0.48) | NOX1MAPTNPSR1MAPK14MAPK13 | |
| SCHEMBL10965277 | 0.86 | MAPK13 (0.59) | NOX1MAPTNPSR1MAPK14MAPK13 | |
| SCHEMBL10969481 | 0.86 | TEK (0.48) | NOX1MAPTNPSR1MAPK14MAPK13 | |
| SCHEMBL11180276 | 0.86 | NOX1 (0.57) | NOX1MAPTNPSR1MAPK14MAPK13 | |
| SCHEMBL10970147 | 0.85 | MAPK14 (0.61) | NOX1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL10968587 | 0.85 | NOX1 (0.46) | NOX1MAPTNPSR1MAPK14MAPK13 | |
| SCHEMBL10965972 | 0.84 | MAPK14 (0.49) | NOX1MAPTMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0043788-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | claimed |
| EP-0043788-A1 | Imidazole derivatives, process for their preparation and their pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | claimed |
| EP-0043788-B1 | IMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| US-4528298-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-09 | — | — | US | disclosed |
| US-4402960-A | Antiinflammatory imidazole derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-06 | — | — | US | disclosed |
| US-4330552-A | Antiinflammatory 4,5-diaryl-2-arylthioimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-05-18 | — | — | US | disclosed |
| US-4330552-A | Antiinflammatory 4,5-diaryl-2-arylthioimidazoles | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1982-05-18 | — | — | US | disclosed |
| EP-0043788-A1 | Imidazole derivatives, process for their preparation and their pharmaceutical compositions | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-01-13 | — | — | EP | disclosed |