SCHEMBL10972437

SCHEMBL10972437

O=C(Nc1ccc(F)c(Cl)c1)c1cccnc1Oc1cccc(C(F)(F)F)c1

nearest known ligand 0.67

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.67
KDM4E B2RXH2 1/20 0.67
MEN1 O00255 1/20 0.67
CYP1A2 P05177 1/20 0.67
CYP2C19 P33261 1/20 0.67
NPSR1 Q6W5P4 1/20 0.67
P2RY1 P47900 14/20 0.64
STK39 Q9UEW8 1/20 0.57
TLR8 Q9NR97 1/20 0.54
TLR7 Q9NYK1 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11247098 0.92 P2RY1 (0.74) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10967923 0.91 KMT2A (0.71) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10975297 0.89 KMT2A (0.59) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10969684 0.87 KMT2A (0.76) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10973612 0.86 KMT2A (0.56) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL3163419 0.86 P2RY1 (0.86) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL10969124 0.85 P2RY1 (0.60) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL135002 0.85 P2RY1 (0.72) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL29549324 0.85 P2RY1 (0.72) KMT2AKDM4EMEN1CYP1A2CYP2C19
SCHEMBL11310639 0.84 KMT2A (0.64) KMT2AKDM4EMEN1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0053011-B1 NEW HERBICIDAL NICOTINAMIDE DERIVATIVES MAY & BAKER LIMITED (GB) 1985-04-03 EP disclosed
EP-0053011-A1 New herbicidal nicotinamide derivatives MAY & BAKER LIMITED (GB) 1982-06-02 EP disclosed