Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cephalothin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 1.00 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 1.00 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 1.00 |
| ▸ | DNMT1 | P26358 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.84 |
| ▸ | GLA | P06280 | 1/20 | 0.84 |
| ▸ | APEX1 | P27695 | 1/20 | 0.84 |
| ▸ | PKM | P14618 | 1/20 | 0.84 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cephalothin SCHEMBL4319851 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL1624515 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL11039891 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL5791156 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL4394024 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL16072835 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL2990 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL9159686 | 1.00 | MAPT (1.00) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL11505696 | 0.99 | MAPT (0.98) | MAPTTDP1NR1I2HPGDCTDSP1 | |
| Cephalothin SCHEMBL1331925 | 0.99 | MAPT (0.98) | MAPTTDP1NR1I2HPGDCTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132987-A1 | Improvements in or relating to deesterification to acids | ELI LILLY AND COMPANY (US) | 1985-02-13 | — | — | EP | disclosed |
| US-4465668-A | CONTAINING A BONDED OLIGOPEPTIDE GROUP | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1984-08-14 | — | — | US | disclosed |
| EP-0034924-B1 | PROCESS FOR PREPARING 3-IODOMETHYL CEPHALOSPORINS | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | disclosed |
| EP-0060422-A2 | Method for improving intestinal absorption of cephalosporin derivatives | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1982-09-22 | — | — | EP | disclosed |
| US-4343937-A | ANTIBIOTICS, BACTERICIDES | MERCK & CO., INC. (US) | 1982-08-10 | — | — | US | disclosed |
| US-4342869-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-08-03 | — | — | US | disclosed |
| US-4342757-A | Cephalosporin antibiotic compositions | MERCK & CO., INC. (US) | 1982-08-03 | — | — | US | disclosed |
| US-4338437-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4338438-A | Cephalosporin antibiotics | MERCK & CO., INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4329454-A | Cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| US-4031082-A | Process for preparing 3-acycloxymethyl-2-cephem compounds | ELI LILLY AND COMPANY (US) | 1977-06-21 | — | — | US | disclosed |
| US-4029651-A | ESTERIFICATION | ELI LILLY AND COMPANY (US) | 1977-06-14 | — | — | US | disclosed |
| US-4014873-A | Process for the production of 7-acylamidocephalosporins | MERCK & CO., INC. (US) | 1977-03-29 | — | — | US | disclosed |
| US-4012379-A | 7-Acetoacetamidocephem compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1977-03-15 | — | — | US | disclosed |
| US-3998816-A | 7-[5-N-(n-Butoxyethoxy carbonyl and 2-chloroethoxy carbonyl)-amino] cephalosporins C | MEIJI SEIKA KAISHA, LTD. (JA) | 1976-12-21 | — | — | US | disclosed |
| US-3994885-A | WITH ALKALI METAL ALKOXIDE, HALOGENATION | ELI LILLY AND COMPANY (US) | 1976-11-30 | — | — | US | disclosed |
| US-3988326-A | Process for N-acylation of 7 amino cephem compounds | MEIJI SEIKA KAISHA, LTD. (JA) | 1976-10-26 | — | — | US | disclosed |
| US-3987040-A | 3-SUBSTITUTED METHYL-7-ACYLAMINO-7-METHOXY-2-CEPHEM-4-CARBOXYLIC ACID AND ITS ESTERS | MERCK & CO., INC. (US) | 1976-10-19 | — | — | US | disclosed |
| US-3953436-A | 3,4-Dicarboxycephalosporins and derivatives | ELI LILLY AND COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
| US-3950329-A | FLUORINATED CEPHALOSPORINS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-04-13 | — | — | US | disclosed |