Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10946796 | 0.80 | KDM4E (0.42) | KDM4EALDH1A1IDO1TDO2TSHR | |
| SCHEMBL10974974 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1IDO1TDO2TSHR | |
| SCHEMBL4666821 | 0.79 | KDM4E (0.33) | KDM4EALDH1A1TDP1LMNAGAA | |
| SCHEMBL10975124 | 0.78 | KDM4E (0.38) | KDM4EALDH1A1IDO1TDO2TSHR | |
| SCHEMBL13370548 | 0.77 | KDM4E (0.36) | KDM4EALDH1A1TDP1LMNAGAA | |
| SCHEMBL14117842 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1IDO1TDO2TSHR | |
| SCHEMBL19689430 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1IDO1TDO2TSHR | |
| SCHEMBL11732491 | 0.76 | KDM4E (0.32) | KDM4EALDH1A1TDP1LMNAGAA | |
| SCHEMBL10975773 | 0.75 | KDM4E (0.36) | KDM4EALDH1A1IDO1TDO2TSHR | |
| SCHEMBL15922747 | 0.74 | KDM4E (0.45) | KDM4EALDH1A1IDO1TDO2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525475-A | Prevention of thrombolic disorder with imidazole derivatives and salts thereof | THOROGOOD PETER B (GB) | 1985-06-25 | — | — | US | disclosed |
| EP-0015002-B1 | 1-SUBSTITUTED IMIDAZOLES, AND SALTS THEREOF, A METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-04-18 | — | — | EP | disclosed |
| US-4328234-A | Imidazole derivatives and salts thereof and pharmaceutical formulations useful in thrombo-embolic disorders | BURROUGHS WELLCOME CO. (US) | 1982-05-04 | — | — | US | disclosed |
| EP-0015002-A1 | 1-substituted imidazoles, and salts thereof, a method for their preparation and pharmaceutical formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-09-03 | — | — | EP | disclosed |