Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 11/20 | 0.53 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | VCP | P55072 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10979289 | 0.91 | GFRA3 (0.51) | MEN1NPC1RAB9AKMT2AAURKA | |
| SCHEMBL5496551 | 0.81 | CTSC (0.44) | AURKASYK | |
| SCHEMBL12846706 | 0.81 | CSNK2A1 (0.50) | MEN1NPC1RAB9AKMT2AAURKA | |
| SCHEMBL11455773 | 0.80 | MAPT (0.56) | MEN1NPC1RAB9AKMT2AAURKA | |
| SCHEMBL12179363 | 0.79 | ESR2 (0.50) | MEN1NPC1RAB9AKMT2AAURKA | |
| SCHEMBL1921278 | 0.78 | ESR1 (0.65) | MEN1NPC1RAB9AKMT2AESR1 | |
| SCHEMBL13605301 | 0.77 | RIPK2 (0.61) | ESR1ESR2 | |
| SCHEMBL4498501 | 0.77 | AURKA (0.63) | MEN1NPC1RAB9AKMT2AAURKA | |
| SCHEMBL5501103 | 0.77 | MAPT (0.52) | MEN1NPC1KMT2AAURKASYK | |
| SCHEMBL10971409 | 0.76 | HDAC3 (0.59) | MEN1NPC1RAB9AKMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164204-A1 | Novel pharmaceutically useful pyrimidines | FISONS plc (GB) | 1985-12-11 | — | — | EP | claimed |
| EP-0164204-A1 | Novel pharmaceutically useful pyrimidines | FISONS plc (GB) | 1985-12-11 | — | — | EP | disclosed |