Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10982300 | 0.86 | PDE10A (0.57) | PDE10AALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL17275587 | 0.85 | PDE10A (1.00) | PDE10AALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL10986089 | 0.81 | PDE10A (0.53) | PDE10AALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL10983412 | 0.80 | PDE10A (0.52) | PDE10AALDH1A1KDM4ETDP1NPC1 | |
| Hydrochloric Acid SCHEMBL10993839 | 0.79 | PDE10A (0.51) | PDE10AKDM4ETDP1 | |
| SCHEMBL17285659 | 0.79 | PDE10A (0.77) | PDE10AALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL17285582 | 0.79 | PDE10A (0.75) | PDE10AALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL17285632 | 0.78 | PDE10A (0.85) | PDE10AALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL10983641 | 0.76 | PDE10A (0.47) | PDE10AALDH1A1NPC1RAB9A | |
| SCHEMBL10987505 | 0.75 | SMN1; SMN2 (0.62) | PDE10AALDH1A1KDM4ETDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4497814-A | 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-02-05 | — | — | US | disclosed |