Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11661048 | 0.85 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10989639 | 0.83 | CNR2 (0.47) | CNR2HTTALDH1A1KDM4EHPGD | |
| SCHEMBL843172 | 0.83 | CNR2 (0.57) | CNR2ALDH1A1KDM4EHPGDKMT2A | |
| SCHEMBL10992081 | 0.82 | CNR2 (0.50) | CNR2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL10995051 | 0.80 | CNR2 (0.44) | CNR2HTTALDH1A1KDM4EHPGD | |
| SCHEMBL10996340 | 0.80 | KDM4E (0.55) | CNR2SMN1; SMN2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL10990806 | 0.80 | CNR2 (0.44) | CNR2HTTALDH1A1KDM4EHPGD | |
| SCHEMBL10998292 | 0.79 | CNR2 (0.46) | CNR2SMN1; SMN2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL11372017 | 0.78 | CNR2 (0.45) | CNR2ALDH1A1KDM4EHPGDPOLB | |
| SCHEMBL10759057 | 0.77 | KMT2A (0.44) | HTTSMN1; SMN2L3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003144-B1 | 4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION, THEIR APPLICATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-08-05 | — | — | EP | claimed |
| US-4549022-A | ANTIBACTERIAL AGENT; STIMULANT ON CENTRAL NERVOUS SYSTEM | HOFFMANN-LA ROCHE INC. (US) | 1985-10-22 | — | — | US | disclosed |
| US-4521535-A | ANTIBACTERIAL AGENTS; STIMULANTS FOR CENTRAL NERVOUS SYSTEM | HOFFMANN-LA ROCHE INC. (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0003144-B1 | 4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION, THEIR APPLICATION | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-08-05 | — | — | EP | disclosed |