Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11004161 | 1.00 | MAPT (0.46) | MAPTNPSR1MEN1PLIN1LMNA | |
| SCHEMBL10353470 | 0.84 | MAPT (0.61) | MAPTNPSR1MEN1PLIN1LMNA | |
| SCHEMBL11002399 | 0.84 | MAPT (0.61) | MAPTNPSR1MEN1PLIN1LMNA | |
| SCHEMBL9386421 | 0.80 | MAPT (0.48) | MAPTNPSR1MEN1LMNAKMT2A | |
| SCHEMBL10744797 | 0.80 | MAPT (0.48) | MAPTNPSR1MEN1LMNAKMT2A | |
| SCHEMBL10481034 | 0.80 | MAPT (0.48) | MAPTNPSR1MEN1LMNAKMT2A | |
| SCHEMBL7378695 | 0.78 | CYP1A2 (0.63) | MAPTNPSR1MEN1PLIN1LMNA | |
| SCHEMBL7378697 | 0.78 | CYP1A2 (0.63) | MAPTNPSR1MEN1PLIN1LMNA | |
| SCHEMBL1508463 | 0.77 | AKR1C3 (0.47) | LMNAPOLBKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL1508462 | 0.77 | AKR1C3 (0.47) | LMNAPOLBKMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4532248-A | Administering 1,4-dihydropyridine derivative exhibiting positive inotropic activity | BAYER AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |