Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11005340 | 0.86 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL11037531 | 0.82 | NPC1 (0.43) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11006639 | 0.82 | NPC1 (0.65) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11003203 | 0.82 | SLC6A4 (0.52) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL11035959 | 0.81 | NPC1 (0.43) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11005771 | 0.81 | SLC6A4 (0.50) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11003392 | 0.81 | SLC6A4 (0.50) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11038643 | 0.79 | NPC1 (0.64) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11000917 | 0.73 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3HRH3 | |
| SCHEMBL11000635 | 0.72 | SLC6A4 (0.48) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4550106-A | ANTIDEPRESSANTS | BOEHRINGER INGELHEIM KG (DE) | 1985-10-29 | — | — | US | disclosed |
| US-4482559-A | ANTIDEPRESSANT | BOEHRINGER INGELHEIM KG (DE) | 1984-11-13 | — | — | US | disclosed |
| EP-0088250-A2 | Basic substituted 4-phenyl-4,5,6,7-tetrahydrothieno(2,3-c) pyridines, process for their preparation and pharmaceutical compositions containing them | BOEHRINGER INGELHEIM KG (DE) | 1983-09-14 | — | — | EP | disclosed |