Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 18/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 14/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000635 | 0.88 | SLC6A4 (0.48) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11218070 | 0.82 | NPC1 (0.47) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10998907 | 0.81 | SLC6A4 (0.39) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11005100 | 0.81 | SLC6A4 (0.44) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11000109 | 0.80 | SLC6A2 (0.46) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11004967 | 0.80 | NPC1 (0.45) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11000327 | 0.80 | SLC6A4 (0.43) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11215415 | 0.79 | SLC6A2 (0.44) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| Hydrochloric Acid SCHEMBL11222430 | 0.79 | SLC6A2 (0.45) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10998903 | 0.78 | NPC1 (0.39) | NPC1RAB9ASLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4550106-A | ANTIDEPRESSANTS | BOEHRINGER INGELHEIM KG (DE) | 1985-10-29 | — | — | US | disclosed |
| US-4482559-A | ANTIDEPRESSANT | BOEHRINGER INGELHEIM KG (DE) | 1984-11-13 | — | — | US | disclosed |
| EP-0088250-A2 | Basic substituted 4-phenyl-4,5,6,7-tetrahydrothieno(2,3-c) pyridines, process for their preparation and pharmaceutical compositions containing them | BOEHRINGER INGELHEIM KG (DE) | 1983-09-14 | — | — | EP | disclosed |