Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.79 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.79 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.79 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | TOP2A | P11388 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117365 | 0.92 | PIK3CG (0.66) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL10920912 | 0.91 | PIK3CG (0.65) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL11010025 | 0.91 | KDM4E (0.69) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL11106729 | 0.83 | KDM4E (0.56) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL10836642 | 0.83 | KDM4E (0.78) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL10922867 | 0.83 | KDM4E (0.69) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL10920267 | 0.83 | KDM4E (0.73) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL10837246 | 0.82 | KDM4E (0.82) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL10839089 | 0.82 | KDM4E (0.81) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E | |
| SCHEMBL29763152 | 0.82 | CA1 (0.73) | PIK3CGPIK3CDPIK3R1PIK3CAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4547503-A | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(oxo-alkyl)-1-piperazinyl]quinoline-3-carboxylic acids and their derivatives, and antibacterial agents containing them | BAYER AKTIENGESELLSCHAFT (DE) | 1985-10-15 | — | — | US | disclosed |
| EP-0113092-A1 | 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(oxoalkyl)-1-piperazinyl)-3-quinoline-carboxylic acids and their derivatives, process for their preparation and antibacterial agents containing them | BAYER AG (DE) | 1984-07-11 | — | — | EP | disclosed |