Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 15/20 | 0.65 |
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959251 | 0.84 | HTT (0.56) | TRPV1EGFR | |
| SCHEMBL2846226 | 0.81 | TRPV1 (0.57) | TRPV1DHODHEGFR | |
| SCHEMBL4871515 | 0.81 | TRPV1 (0.57) | TRPV1DHODHEGFR | |
| SCHEMBL10955880 | 0.81 | MKNK1 (0.54) | TRPV1EGFR | |
| SCHEMBL11008088 | 0.81 | CCNT1 (0.46) | TRPV1EGFR | |
| SCHEMBL10956616 | 0.81 | EGFR (0.56) | TRPV1EGFR | |
| SCHEMBL10960189 | 0.81 | MKNK1 (0.54) | TRPV1 | |
| SCHEMBL10339770 | 0.80 | POLB (0.56) | TRPV1EGFR | |
| Hydrochloric Acid SCHEMBL11055611 | 0.79 | CCNT1 (0.44) | TRPV1EGFR | |
| SCHEMBL4193964 | 0.79 | TRPV1 (1.00) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067630-B1 | PYRIMIDINE DERIVATIVES, A PROCESS FOR PREPARING THEM AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM | SANKYO COMPANY LIMITED (JP) | 1985-05-08 | — | — | EP | disclosed |
| US-4450162-A | Pyrimidine derivatives and a pharmaceutical composition containing them | SANKYO COMPANY, LIMITED (JP) | 1984-05-22 | — | — | US | disclosed |
| EP-0067630-A1 | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-22 | — | — | EP | disclosed |