Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11009980 | 1.00 | CYP11B1 (0.47) | CYP11B1CYP11B2CA1CA2ALDH1A1 | |
| SCHEMBL6737213 | 0.87 | CYP11B1 (0.53) | CYP11B1CYP11B2CA1CA2ALDH1A1 | |
| SCHEMBL23832223 | 0.87 | CYP11B1 (0.47) | CYP11B1CYP11B2CA1CA2ALDH1A1 | |
| SCHEMBL6737207 | 0.87 | CYP11B1 (0.53) | CYP11B1CYP11B2CA1CA2ALDH1A1 | |
| SCHEMBL23839943 | 0.83 | CYP11B1 (0.48) | CYP11B1CYP11B2CA1CA2ALDH1A1 | |
| SCHEMBL9476052 | 0.81 | CYP11B1 (0.51) | CYP11B1CYP11B2CA1CA2ALDH1A1 | |
| SCHEMBL16110489 | 0.79 | CYP2C9 (0.50) | CYP11B1CYP11B2ALDH1A1MAPTGSK3B | |
| SCHEMBL30144859 | 0.79 | CYP2C9 (0.50) | CYP11B1CYP11B2ALDH1A1MAPTGSK3B | |
| SCHEMBL16110488 | 0.79 | CYP2C9 (0.50) | CYP11B1CYP11B2ALDH1A1MAPTGSK3B | |
| SCHEMBL4291331 | 0.77 | CYP1A2 (0.51) | CA1CA2ALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4530842-A | Containing a cyano substitution in position 3 | SANDOZ LTD. (CH) | 1985-07-23 | — | — | US | disclosed |
| WO-1983004024-A1 | 2(1H)-PYRIDONE DERIVATIVES, PREPARATION THEREOF AND COMPOSITION CONTAINING THEM | SANDOZ AG (CH) | 1983-11-24 | — | — | WO | disclosed |