Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.56 |
| ▸ | PDE5A | O76074 | 3/20 | 0.56 |
| ▸ | PDE1A | P54750 | 3/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11016023 | 0.89 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL10442451 | 0.84 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11017499 | 0.83 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9196954 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11014088 | 0.80 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11018621 | 0.78 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9194085 | 0.76 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9373694 | 0.73 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL9194840 | 0.73 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL11017101 | 0.73 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0157637-A2 | Heterocyclic compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1985-10-09 | — | — | EP | disclosed |