Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019275 | 0.92 | CHEK2 (0.48) | KDM4EPOLBMAPTHSP90AA1SMN1; SMN2 | |
| SCHEMBL10760161 | 0.88 | RHEB (0.47) | KDM4EMAPTHSP90AA1SMN1; SMN2LMNA | |
| SCHEMBL11020731 | 0.85 | NPC1 (0.44) | POLBMAPTHSP90AA1TP53RAB9A | |
| SCHEMBL10759746 | 0.85 | NPC1 (0.44) | KDM4EHSP90AA1MEN1KMT2ALMNA | |
| SCHEMBL11022048 | 0.84 | CHEK2 (0.55) | HSP90AA1RAB9ANPC1PKMCHEK2 | |
| SCHEMBL11018145 | 0.83 | NPC1 (0.45) | POLBHSP90AA1SMN1; SMN2TP53RAB9A | |
| SCHEMBL11020382 | 0.82 | NPC1 (0.42) | HSP90AA1RAB9ANPC1PKMCHEK2 | |
| SCHEMBL11017271 | 0.82 | NPC1 (0.47) | HSP90AA1SMN1; SMN2TP53RAB9ANPC1 | |
| SCHEMBL11019650 | 0.81 | CHEK2 (0.43) | KDM4EMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL11019907 | 0.80 | CHEK2 (0.53) | KDM4EMAPTHSP90AA1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |