Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | POLB | P06746 | 2/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA4 | P22748 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.54 |
| ▸ | MC5R | P33032 | 1/20 | 0.54 |
| ▸ | MC3R | P41968 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10437146 | 0.93 | KDM4E (0.71) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL28646350 | 0.91 | KDM4E (0.68) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL29103230 | 0.90 | KDM4E (0.68) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL30657727 | 0.90 | KDM4E (0.68) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL31606732 | 0.86 | KDM4E (0.75) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL5972208 | 0.86 | KDM4E (0.75) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL10518881 | 0.86 | KDM4E (0.65) | KDM4EPOLBATMCA12CA1 | |
| SCHEMBL11654613 | 0.86 | KDM4E (0.65) | KDM4EPOLBATMCA12CA1 | |
| SCHEMBL3269547 | 0.85 | KDM4E (0.74) | KDM4EPOLBHDAC3HDAC1HDAC2 | |
| SCHEMBL9672348 | 0.84 | KDM4E (1.00) | KDM4EPOLBHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161599-A2 | Benzazepine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |