Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025025 | 0.88 | MAPT (0.38) | MAPTNPC1ABCB1ABCC1MEN1 | |
| SCHEMBL11023771 | 0.88 | MAPT (0.43) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL9832729 | 0.87 | MAPT (0.57) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL9834277 | 0.87 | MAPT (0.57) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL9832294 | 0.84 | MAPT (0.57) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL9833142 | 0.84 | MAPT (0.57) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL9831885 | 0.84 | MAPT (0.43) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL9833046 | 0.84 | MAPT (0.43) | MAPTNPC1ABCB1ABCC1POLB | |
| SCHEMBL11023012 | 0.84 | MAPT (0.38) | MAPTNPC1ABCB1ABCC1MEN1 | |
| SCHEMBL9833886 | 0.81 | KMT2A (0.43) | MAPTNPC1ABCB1ABCC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0161632-A2 | Pyrrolo-benzimidazoles, process for their preparation, medicaments containing them and intermediates | Roche Diagnostics GmbH (DE) | 1985-11-21 | — | — | EP | disclosed |