Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 19/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1102146 | 0.91 | MPL (0.84) | MPL | |
| SCHEMBL1102200 | 0.91 | MPL (0.84) | MPL | |
| SCHEMBL1102086 | 0.88 | MPL (0.85) | MPL | |
| SCHEMBL1102087 | 0.88 | MPL (0.85) | MPL | |
| SCHEMBL1102201 | 0.86 | MPL (0.72) | MPL | |
| SCHEMBL1102157 | 0.84 | MPL (1.00) | MPL | |
| SCHEMBL1091509 | 0.84 | MPL (1.00) | MPL | |
| SCHEMBL1102030 | 0.84 | MPL (1.00) | MPL | |
| SCHEMBL1102032 | 0.84 | MPL (0.79) | MPL | |
| SCHEMBL1102176 | 0.84 | MPL (0.85) | MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153671-B2 | Heterotetracyclic compounds as TPO mimetics | IRM LLC (BM) | 2012-04-10 | — | — | US | disclosed |