Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL284318 | 0.94 | ATM (0.56) | ATMALDH1A1KDM4EPOLBEPHX2 | |
| SCHEMBL284342 | 0.94 | ATM (0.56) | ATMALDH1A1KDM4EPOLBEPHX2 | |
| SCHEMBL50350 | 0.94 | — | — | |
| SCHEMBL284319 | 0.94 | ATM (0.56) | ATMALDH1A1KDM4EPOLBEPHX2 | |
| Water SCHEMBL27364290 | 0.92 | — | — | |
| Hydrochloric Acid SCHEMBL27752288 | 0.92 | — | — | |
| SCHEMBL852876 | 0.90 | ATM (0.48) | ATMALDH1A1KDM4EPOLBEPHX2 | |
| SCHEMBL852875 | 0.90 | ATM (0.48) | ATMALDH1A1KDM4EPOLBEPHX2 | |
| Nitrogen SCHEMBL27858935 | 0.89 | — | — | |
| SCHEMBL23735497 | 0.86 | EPHX2 (0.61) | ATMALDH1A1KDM4EEPHX2MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073391-B1 | METAL COMPLEXES OF 1-AMINOCYCLOPROPANE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PLANT GROWTH REGULATORS | BAYER AG (DE) | 1985-03-06 | — | — | EP | disclosed |
| EP-0073391-A1 | Metal complexes of 1-aminocyclopropane-carboxylic acids, process for their preparation and their use as plant growth regulators | BAYER AG (DE) | 1983-03-09 | — | — | EP | disclosed |