SCHEMBL1102787

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1103639	0.94	TNF (0.40)	TNFBACE1ENPP3ENPP1NTSR1
	SCHEMBL1102772	0.93	TNF (0.40)	TNFBACE1ENPP3ENPP1MAPK11
	SCHEMBL1103666	0.93	TNF (0.39)	TNFBACE1ENPP3ENPP1NTSR1
	SCHEMBL1103663	0.91	TNF (0.38)	TNFBACE1NTSR1PIK3CDTLR8
	SCHEMBL1104949	0.90	TNF (0.38)	TNFBACE1ENPP3ENPP1MAPK11
	SCHEMBL1102962	0.90	TNF (0.40)	TNFBACE1ENPP3ENPP1NTSR1
	SCHEMBL1102965	0.90	TNF (0.39)	TNFBACE1ENPP3ENPP1CHEK1
	SCHEMBL1102563	0.89	PDK2 (0.40)	TNFPIK3CDPDK2
	SCHEMBL1102896	0.89	TNF (0.39)	TNFBACE1ENPP3ENPP1MAPK11
	SCHEMBL1102676	0.88	CYP11B1 (0.41)	TNFMAPK11MAPK14SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.