Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.51 |
| ▸ | RAF1 | P04049 | 5/20 | 0.51 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | MST1R | Q04912 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | MB | P02144 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028244 | 0.83 | BRAF (0.57) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL1161282 | 0.77 | BRAF (0.54) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL11029853 | 0.77 | BRAF (0.54) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL11032412 | 0.77 | BRAF (0.54) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL1161163 | 0.77 | BRAF (0.54) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL11027622 | 0.75 | GAA (0.40) | BRAFRAF1DDR2OPRM1OPRD1 | |
| SCHEMBL11025537 | 0.74 | BRAF (0.52) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL9905443 | 0.73 | MST1R (0.51) | BRAFRAF1DDR2MST1REGFR | |
| SCHEMBL1161084 | 0.71 | BRAF (0.57) | BRAFRAF1DDR2MST1R | |
| SCHEMBL11030333 | 0.71 | BRAF (0.62) | BRAFRAF1DDR2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569295-B2 | Bicyclic urea compounds | MERCK PATENT GMBH (DE) | 2013-10-29 | — | — | US | disclosed |
| EP-2461869-B1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2013-08-21 | — | — | EP | disclosed |
| US-20120190654-A1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190654-A1 | NOVEL BICYCLIC UREA COMPOUNDS | CCNC, CCNI, CCNA1 | BRAF 582/4885RAF1 1266/4885DDR2 4285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.