Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 3/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.35 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11025701 | 0.85 | ACE (0.61) | ACEOPRK1OGFRL1 | |
| SCHEMBL11026370 | 0.84 | ACE (0.68) | ACEPHGDH | |
| SCHEMBL11026018 | 0.83 | ACE (0.40) | ACEPHGDH | |
| SCHEMBL4798449 | 0.76 | BACE1 (0.41) | ACEPHGDH | |
| SCHEMBL4798432 | 0.76 | BACE1 (0.41) | ACEPHGDH | |
| SCHEMBL4798440 | 0.76 | BACE1 (0.41) | ACEPHGDH | |
| SCHEMBL2083817 | 0.73 | BACE1 (0.44) | ACEPHGDH | |
| SCHEMBL2083821 | 0.73 | BACE1 (0.44) | ACEPHGDH | |
| SCHEMBL2083819 | 0.73 | BACE1 (0.44) | ACEPHGDH | |
| SCHEMBL11023988 | 0.72 | ACE (0.60) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049842-B1 | SUBSTITUTED ENANTHOLACTAM DERIVATIVES, A PROCESS FOR THE PREPARATION AND A PHARMACEUTICAL COMPOSITION USEFUL IN THE TREATMENT OF HYPERTENSION COMPRISING THE SAME, AND INTERMEDIATES | MERCK & CO. INC. (US) | 1985-08-28 | — | — | EP | disclosed |
| US-4396616-A | DIURETICS, ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1983-08-02 | — | — | US | disclosed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | disclosed |