Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 13/20 | 0.57 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11030657 | 0.99 | SPHK1 (0.55) | SPHK1SPHK2S1PR2S1PR4S1PR1 | |
| SCHEMBL11031473 | 0.96 | SPHK1 (0.51) | SPHK1SPHK2S1PR2S1PR4S1PR1 | |
| SCHEMBL11032593 | 0.95 | SPHK1 (0.57) | SPHK1SPHK2S1PR2S1PR4S1PR1 | |
| SCHEMBL11027967 | 0.95 | SPHK1 (0.50) | SPHK1SPHK2S1PR2S1PR4S1PR1 | |
| SCHEMBL11030656 | 0.93 | SPHK1 (0.55) | SPHK1SPHK2S1PR2S1PR4S1PR1 | |
| SCHEMBL11027792 | 0.93 | SPHK1 (0.48) | SPHK1SPHK2ALDH1A1LMNA | |
| SCHEMBL6451667 | 0.91 | SPHK1 (0.47) | SPHK1SPHK2HSD17B10 | |
| SCHEMBL6453742 | 0.91 | SPHK1 (0.47) | SPHK1SPHK2HSD17B10 | |
| SCHEMBL6453746 | 0.91 | SPHK1 (0.47) | SPHK1SPHK2HSD17B10 | |
| SCHEMBL6451664 | 0.91 | SPHK1 (0.47) | SPHK1SPHK2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4432885-A | Decalins | HOFFMANN-LA ROCHE INC. (US) | 1984-02-21 | — | — | US | disclosed |