Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.51 |
| ▸ | MTOR | P42345 | 4/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KIF5B | P33176 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164000 | 0.70 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL165181 | 0.69 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL168583 | 0.68 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL2790651 | 0.67 | PIK3CA (0.42) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL11030218 | 0.67 | PIK3CA (0.57) | PIK3CAMTOR | |
| SCHEMBL168179 | 0.65 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL2789837 | 0.65 | PIK3CA (1.00) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL2789156 | 0.64 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL752861 | 0.64 | PIK3CA (0.55) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL755704 | 0.64 | PIK3CA (0.53) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | PIK3CA 1/4885PIK3CB 8/4885PIK3CG 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.