Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.58 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16161710 | 0.94 | MTOR (0.54) | MTORPIK3CACCNE1CDK2PIK3CB | |
| SCHEMBL11031207 | 0.92 | MTOR (0.53) | MTORPIK3CAALDH1A1 | |
| SCHEMBL11029448 | 0.91 | MTOR (0.53) | MTORPIK3CACCNE1CDK2PIK3CB | |
| SCHEMBL16161620 | 0.90 | MTOR (0.52) | MTORPIK3CACCNE1CDK2PIK3CB | |
| SCHEMBL11026350 | 0.90 | MTOR (0.58) | MTORPIK3CACCNE1CDK2PIK3CB | |
| SCHEMBL16161680 | 0.90 | MTOR (0.60) | MTORPIK3CACCNE1CDK2PIK3CB | |
| SCHEMBL11026844 | 0.90 | MTOR (0.56) | MTORPIK3CACCNE1CDK2ALDH1A1 | |
| SCHEMBL11026308 | 0.88 | MTOR (0.56) | MTORPIK3CACCNE1CDK2PIK3CB | |
| SCHEMBL11029456 | 0.88 | MTOR (0.58) | MTORPIK3CAALDH1A1PIK3CB | |
| SCHEMBL751618 | 0.87 | MTOR (0.58) | MTORPIK3CAALDH1A1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | AMGEN INC. (US) | 2012-07-26 | — | — | US | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190666-A1 | Heteroaryl Compounds as PIKK Inhibitors | PIK3CA, PIKFYVE, PIK3CD | MTOR 21/4885PIK3CA 1/4885CCNE1 1797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.