Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.51 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SCN4A | P35499 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591879 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL4473488 | 1.00 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL11130621 | 0.95 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL11130618 | 0.95 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL20611377 | 0.93 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| Tetradecane SCHEMBL27504192 | 0.93 | SMN1; SMN2 (0.59) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL5233459 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL17069045 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL5233467 | 0.89 | SMN1; SMN2 (0.63) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL17401020 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2ALDH1A1KMT2APOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4432971-A | HYPOTENSIVE AGENTS AND ANGIOTENSIN INHIBITION | E. R. SQUIBB & SONS, INC. (US) | 1984-02-21 | — | — | US | disclosed |
| EP-0071544-A1 | Phosphonamidate compounds | E.R. Squibb & Sons, Inc. (US) | 1983-02-09 | — | — | EP | disclosed |