Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10924606 | 0.90 | EGFR (0.56) | EGFRSRCKCNH2HDAC1HTR1A | |
| SCHEMBL11038024 | 0.87 | KDM4E (0.54) | EGFRSRCKCNH2HDAC1KDM4E | |
| SCHEMBL11037178 | 0.86 | KCNH2 (0.44) | EGFRKCNH2HDAC1KDM4EALDH1A1 | |
| SCHEMBL11036464 | 0.86 | KCNH2 (0.44) | EGFRSRCKCNH2HDAC1HTR6 | |
| SCHEMBL10924684 | 0.84 | KCNH2 (0.44) | EGFRSRCKCNH2HDAC1HTR1A | |
| SCHEMBL10925293 | 0.84 | CYP3A4 (0.52) | KCNH2HDAC1HTR1ADRD2DRD4 | |
| SCHEMBL10925734 | 0.83 | KCNH2 (0.44) | EGFRKCNH2HDAC1KDM4EALDH1A1 | |
| SCHEMBL10832301 | 0.83 | EGFR (0.39) | EGFRSRCKCNH2HDAC1KDM4E | |
| SCHEMBL10927024 | 0.82 | EGFR (0.51) | EGFRSRCKCNH2HDAC1KDM4E | |
| SCHEMBL10832637 | 0.82 | HTR2A (0.54) | KCNH2HDAC1HTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038298-B1 | ISOXAZOLYL INDOLAMINES | SANDOZ AG (CH) | 1984-07-25 | — | — | EP | disclosed |
| US-4453001-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4415568-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1983-11-15 | — | — | US | disclosed |
| US-4336378-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |
| EP-0038298-A1 | Isoxazolyl indolamines | SANDOZ AG (CH) | 1981-10-21 | — | — | EP | disclosed |