Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 12/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.38 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.38 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039160 | 0.71 | POLB (0.46) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL11038060 | 0.71 | SMN1; SMN2 (0.51) | PDE7ASMN1; SMN2PDE4BKMT2APKM | |
| SCHEMBL1699146 | 0.68 | TSHR (0.47) | POLBALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11167231 | 0.68 | PDE7A (0.40) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL29354937 | 0.67 | KMT2A (0.56) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL19807935 | 0.64 | ALPI (0.40) | ALDH1A1SMN1; SMN2GAARAB9APDE3B | |
| SCHEMBL7097205 | 0.63 | PDE7A (0.39) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL7097206 | 0.63 | PDE7A (0.39) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL7097210 | 0.63 | PDE7A (0.39) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B | |
| SCHEMBL7097211 | 0.63 | PDE7A (0.39) | PDE7APOLBALDH1A1SMN1; SMN2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0043054-B1 | PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-10-03 | — | — | EP | claimed |
| US-4376121-A | Antiallerigically-active imidazothienopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | claimed |
| EP-0043054-A2 | Pyrimidine derivatives, their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-01-06 | — | — | EP | claimed |
| US-4376121-A | Antiallerigically-active imidazothienopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |