Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | TACR2 | P21452 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SHBG | P04278 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321048 | 0.95 | ESR1 (0.47) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL28364216 | 0.90 | ESR1 (0.55) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10527660 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10527669 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10529788 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10528698 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10527824 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10533741 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10528697 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 | |
| SCHEMBL10525992 | 0.85 | HSD17B10 (0.54) | MAOAMAOBESR1ADRA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |