Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | MEN1 | O00255 | 11/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.66 |
| ▸ | LMNA | P02545 | 8/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 11/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | F2 | P00734 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 6/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038508 | 1.00 | NPC1 (0.72) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL13842694 | 0.84 | NPC1 (1.00) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL11136424 | 0.80 | MAPT (0.68) | NPC1MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL19122688 | 0.80 | NPC1 (0.68) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL13015638 | 0.80 | NPC1 (0.72) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL5458121 | 0.78 | NPC1 (0.65) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL21484844 | 0.77 | MEN1 (0.66) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL11038506 | 0.77 | CSNK2A1 (0.60) | NPC1MAPK1HSD17B10MEN1KMT2A | |
| SCHEMBL16434443 | 0.76 | NPC1 (0.62) | NPC1MAPK1KDM4EHSD17B10MEN1 | |
| SCHEMBL25474816 | 0.76 | NPC1 (0.58) | NPC1MAPK1KDM4EHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052564-B1 | DERIVATIVES OF 2-THIAZOLYL-OXAMIC ACID SUBSTITUTED IN POSITION 4 BY A THIENYL OR FURYL RADICAL, THEIR PREPARATION AND USE AS PHARMACEUTICAL PREPARATIONS | PIERRE FABRE S.A. (FR) | 1984-10-17 | — | — | EP | claimed |