⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24412340 | 0.81 | GABRR1 (0.45) | — | |
| SCHEMBL15840421 | 0.80 | — | — | |
| SCHEMBL8164627 | 0.79 | — | — | |
| SCHEMBL340609 | 0.79 | — | — | |
| SCHEMBL31170387 | 0.79 | — | — | |
| SCHEMBL24344302 | 0.79 | — | — | |
| SCHEMBL18541363 | 0.79 | — | — | |
| SCHEMBL20887548 | 0.79 | — | — | |
| SCHEMBL22659276 | 0.79 | — | — | |
| SCHEMBL16538924 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068999-B1 | DERIVATIVES OF 1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXAMIDES (Z), THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | PIERRE FABRE S.A. (FR) | 1985-05-22 | — | — | EP | claimed |
| US-4478836-A | 1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system | PIERRE FABRE S.A. (FR) | 1984-10-23 | — | — | US | claimed |
| EP-0068999-A1 | Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | claimed |
| EP-0068999-B1 | DERIVATIVES OF 1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXAMIDES (Z), THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | PIERRE FABRE S.A. (FR) | 1985-05-22 | — | — | EP | disclosed |
| EP-0068999-B1 | DERIVATIVES OF 1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXAMIDES (Z), THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | PIERRE FABRE S.A. (FR) | 1985-05-22 | — | — | EP | disclosed |
| US-4478836-A | 1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system | PIERRE FABRE S.A. (FR) | 1984-10-23 | — | — | US | disclosed |
| US-4478836-A | 1-Aryl 2-aminomethyl cyclopropane carboxyamide (Z) derivatives and their use as useful drugs in the treatment of disturbances of the central nervous system | PIERRE FABRE S.A. (FR) | 1984-10-23 | — | — | US | disclosed |
| EP-0068999-A1 | Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |
| EP-0068999-A1 | Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |
| EP-0068999-A1 | Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |