SCHEMBL11045985

SCHEMBL11045985

C[C@H]1Cc2ccccc2O[C@@H]1c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 1/20 0.44
GABRA1 P14867 2/20 0.43
GABRB2 P47870 2/20 0.43
MAOB P27338 8/20 0.42
KDM4E B2RXH2 2/20 0.42
HSD17B10 Q99714 2/20 0.42
ADORA3 P0DMS8 1/20 0.42
AR P10275 1/20 0.42
CYP19A1 P11511 1/20 0.42
CHRM2 P08172 2/20 0.39
CHRM4 P08173 2/20 0.39
CHRM5 P08912 2/20 0.39
CHRM1 P11229 2/20 0.39
CHRM3 P20309 2/20 0.39
CYP2C19 P33261 1/20 0.39
SLC8A1 P32418 1/20 0.38
NISCH Q9Y2I1 1/20 0.38
TSHR P16473 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23867147 1.00 HSP90AB1 (0.44) HSP90AB1GABRA1GABRB2MAOBKDM4E
SCHEMBL11045987 1.00 HSP90AB1 (0.44) HSP90AB1GABRA1GABRB2MAOBKDM4E
SCHEMBL11044980 1.00 HSP90AB1 (0.44) HSP90AB1GABRA1GABRB2MAOBKDM4E
SCHEMBL11044983 1.00 HSP90AB1 (0.44) HSP90AB1GABRA1GABRB2MAOBKDM4E
SCHEMBL11044986 1.00 HSP90AB1 (0.44) HSP90AB1GABRA1GABRB2MAOBKDM4E
SCHEMBL18655389 0.80 DYRK1A (0.57) HSP90AB1GABRA1GABRB2KDM4EHSD17B10
SCHEMBL4363910 0.80 AR (0.50) MAOBHSD17B10ARCYP19A1SLC8A1
SCHEMBL16376659 0.79 CYP2C19 (0.47) HSP90AB1GABRA1GABRB2MAOBKDM4E
SCHEMBL8504530 0.79 CHRM2 (0.41) GABRA1GABRB2MAOBCHRM2CHRM4
SCHEMBL1659934 0.78 CYP3A4 (0.48) HSP90AB1GABRA1GABRB2MAOBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0025599-A1 Benzopyran compounds, useful as chemotherapeutic agents THE WELLCOME FOUNDATION LIMITED (GB) 1981-03-25 EP claimed
EP-0025599-B1 BENZOPYRAN COMPOUNDS, USEFUL AS CHEMOTHERAPEUTIC AGENTS THE WELLCOME FOUNDATION LIMITED (GB) 1984-12-19 EP disclosed
US-4452991-A OR BENZO(B)INDENO (2,1-E) PYRANS OR BENZO(C)XANTHENES BATCHELOR JOHN F (GB) 1984-06-05 US disclosed
EP-0025599-A1 Benzopyran compounds, useful as chemotherapeutic agents THE WELLCOME FOUNDATION LIMITED (GB) 1981-03-25 EP disclosed