SCHEMBL11051286

SCHEMBL11051286

CCc1cccc(F)c1NC(=O)NC(=N)N

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 2/20 0.56
SCN5A Q14524 2/20 0.56
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
KDM4E B2RXH2 1/20 0.40
ALDH1A1 P00352 1/20 0.40
ANPEP P15144 1/20 0.39
DRD2 P14416 1/20 0.39
HTR2A P28223 1/20 0.39
HTR2B P41595 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
NLRP3 Q96P20 1/20 0.39
RAB9A P51151 1/20 0.39
PKM P14618 2/20 0.38
CHIT1 Q13231 1/20 0.38
MAPT P10636 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11282018 0.91 CACNA1C (0.46) CACNA1CSCN5AKMT2AMEN1KDM4E
SCHEMBL10939575 0.90 SCN5A (0.68) CACNA1CSCN5AKDM4EALDH1A1ANPEP
SCHEMBL11661029 0.88 CACNA1C (0.44) CACNA1CSCN5AKMT2AMEN1KDM4E
SCHEMBL11662569 0.88 CACNA1C (0.44) CACNA1CSCN5AKMT2AMEN1DRD2
SCHEMBL11049556 0.86 KMT2A (0.54) CACNA1CSCN5AKMT2AMEN1KDM4E
SCHEMBL11137123 0.84 HTT (0.43) CACNA1CSCN5AKMT2AMEN1KDM4E
SCHEMBL10613025 0.84 CACNA1C (0.51) CACNA1CSCN5AKMT2AMEN1KDM4E
SCHEMBL7169954 0.84 CACNA1C (0.57) CACNA1CSCN5AKMT2AMEN1KDM4E
SCHEMBL11060254 0.83 SCN5A (0.59) CACNA1CSCN5AKDM4EALDH1A1ANPEP
SCHEMBL10941132 0.83 CACNA1C (0.56) CACNA1CSCN5AKDM4EALDH1A1ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4326075-A ANTIDIARRHEA AGENTS WILLIAM H. RORER, INC. (US) 1982-04-20 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4203920-A ANTIDIARRHEAL WILLIAM H. RORER, INC. (US) 1980-05-20 US disclosed
US-4117165-A ANTIULCER, HYPOTENSIVE AGENTS WILLIAM H. RORER, INC. (US) 1978-09-26 US disclosed
US-4060635-A Amidinoureas for treating diarrhea WILLIAM H. RORER, INC. (US) 1977-11-29 US disclosed