SCHEMBL11051474

SCHEMBL11051474

CC(C)(C)c1cc(CCC(=O)N2CNC[N+](C(=O)CCc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)(C(=O)CCc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)C2)cc(C(C)(C)C)c1O

nearest known ligand 0.58

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.53
MEN1 O00255 2/20 0.53
GAA P10253 7/20 0.43
MAOB P27338 3/20 0.37
MAOA P21397 2/20 0.37
ALDH1A1 P00352 4/20 0.35
LMNA P02545 1/20 0.35
TSHR P16473 1/20 0.35
ACHE P22303 1/20 0.35
KDM4E B2RXH2 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6360904 0.82 KMT2A (0.63) KMT2AMEN1GAAMAOBMAOA
SCHEMBL28493854 0.81 KMT2A (0.62) KMT2AMEN1GAAMAOBMAOA
SCHEMBL28925050 0.77 KMT2A (0.57) KMT2AMEN1GAAMAOBMAOA
SCHEMBL10963429 0.76 KMT2A (0.69) KMT2AMEN1GAAMAOBMAOA
SCHEMBL78349 0.76 KMT2A (0.69) KMT2AMEN1GAAMAOBMAOA
SCHEMBL8608828 0.76 GAA (0.65) KMT2AMEN1GAAMAOBMAOA
SCHEMBL28022592 0.75 KMT2A (0.67) KMT2AMEN1GAAMAOBMAOA
SCHEMBL8077617 0.74 KMT2A (0.66) KMT2AMEN1GAAMAOBMAOA
SCHEMBL8606000 0.71 GAA (0.61) KMT2AMEN1GAAMAOBMAOA
SCHEMBL7185809 0.69 KMT2A (0.59) KMT2AMEN1GAAMAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4448969-A Cyclic ether or carbonate alkylation products of 2,2,5,5-tetramethylimidazolidin-4-one and derivatives, their preparation, and their use as stabilizers for _synthetic polymers FERRO CORPORATION (US) 1984-05-15 US disclosed
US-4146531-A HEAT AND OXIDATION RESISTANCE CIBA-GEIGY CORPORATION (US) 1979-03-27 US disclosed
US-4070338-A OXIDATION, HEAT AND DISCOLORATION RESISTANCE CIBA-GEIGY CORPORATION (US) 1978-01-24 US disclosed
US-4069197-A HYDANTOIN OR TETRAHYDROPYRIMIDINE-2,4-DIONE ESTERS CIBA-GEIGY CORPORATION (US) 1978-01-17 US disclosed
US-4044019-A STABILIZERS CIBA-GEIGY CORPORATION (US) 1977-08-23 US disclosed
US-4021468-A STABILIZERS FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1977-05-03 US disclosed
US-3992420-A STABILIZERS FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1976-11-16 US disclosed
US-3971757-A STABILIZERS FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1976-07-27 US disclosed
US-3966711-A 4-Alkyl-1,4-diaza-5-oxo-cycloheptanes and their 1-oxyls CIBA-GEIGY CORPORATION (US) 1976-06-29 US disclosed
US-3939175-A STABILIZER CIBA-GEIGY CORPORATION (US) 1976-02-17 US disclosed