Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15426132 | 0.77 | MAPT (0.67) | MEN1KMT2AKDM4EMAPTHPGD | |
| SCHEMBL9368433 | 0.75 | NPC1 (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2851197 | 0.75 | MAPT (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL4872580 | 0.75 | MAPT (0.46) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL9373167 | 0.75 | PRMT1 (0.47) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL10956616 | 0.75 | EGFR (0.56) | MEN1KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL10960189 | 0.75 | MKNK1 (0.54) | MEN1KMT2AKDM4EMAPTHPGD | |
| SCHEMBL10955880 | 0.75 | MKNK1 (0.54) | MEN1KMT2AKDM4EMAPTHPGD | |
| SCHEMBL11008088 | 0.75 | CCNT1 (0.46) | MEN1KMT2AKDM4EMAPTHPGD | |
| SCHEMBL10959251 | 0.75 | HTT (0.56) | MEN1KMT2AMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4450162-A | Pyrimidine derivatives and a pharmaceutical composition containing them | SANKYO COMPANY, LIMITED (JP) | 1984-05-22 | — | — | US | disclosed |
| EP-0067630-A1 | Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-22 | — | — | EP | disclosed |