Bromide

Bromide

SCHEMBL11060728

Ic1ccccc1C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.[Br-]

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.44
SNCA P37840 2/20 0.43
TAAR1 Q96RJ0 1/20 0.42
IDO1 P14902 2/20 0.41
CYP1A2 P05177 3/20 0.37
CYP2D6 P10635 3/20 0.37
CYP2C19 P33261 2/20 0.37
CYP2C9 P11712 1/20 0.37
TSHR P16473 2/20 0.35
ALDH1A1 P00352 1/20 0.35
KDM1A O60341 1/20 0.34
C1R P00736 1/20 0.32
NPC1 O15118 1/20 0.30
MTOR P42345 1/20 0.30
RAB9A P51151 1/20 0.30
APP P05067 1/20 0.30
TACR1 P25103 1/20 0.30
TP53 P04637 1/20 0.30
CYP3A4 P08684 1/20 0.30
THPO P40225 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11062554 0.96 HIF1A (0.44) HIF1ASNCATAAR1IDO1CYP1A2
Bromide SCHEMBL2446627 0.84 HIF1A (0.55) HIF1ASNCATAAR1CYP1A2CYP2D6
Hydrochloric Acid SCHEMBL9292231 0.80 HIF1A (0.55) HIF1ASNCATAAR1CYP1A2CYP2D6
Bromide SCHEMBL8464686 0.78 HIF1A (0.48) HIF1ASNCACYP1A2CYP2D6CYP2C19
Bromide SCHEMBL2552144 0.78 BACE1 (0.39) HIF1ASNCACYP1A2CYP2D6CYP2C19
Bromide SCHEMBL2557877 0.78 SNCA (0.37) HIF1ASNCACYP1A2CYP2D6CYP2C19
Bromide SCHEMBL4287071 0.77 HIF1A (0.46) HIF1ASNCACYP1A2CYP2D6CYP2C19
Bromide SCHEMBL1465677 0.75 HIF1A (0.44) HIF1ASNCACYP1A2CYP2D6CYP2C19
Bromide SCHEMBL4175689 0.75 HIF1A (0.44) HIF1ASNCACYP1A2CYP2D6CYP2C19
Bromide SCHEMBL2451357 0.75 HIF1A (0.44) HIF1ASNCATAAR1TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4446123-A QUATERNARY AMMONIUM, PHOSPHONIUM, OR ARSONIUM HALIDE HAHNEMANN UNIVERSITY (US) 1984-05-01 US claimed
US-4446123-A QUATERNARY AMMONIUM, PHOSPHONIUM, OR ARSONIUM HALIDE HAHNEMANN UNIVERSITY (US) 1984-05-01 US disclosed