Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | CA12 | O43570 | 4/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31387794 | 0.89 | TSHR (0.57) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL31163774 | 0.85 | TSHR (0.48) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL764943 | 0.83 | TSHR (0.50) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL31387748 | 0.82 | TSHR (0.46) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL31387753 | 0.81 | TSHR (0.54) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL15071363 | 0.81 | TSHR (0.48) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL31252287 | 0.81 | TSHR (0.48) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL9103267 | 0.79 | TSHR (0.57) | TSHRCA12CA14RECQLKMT2A | |
| SCHEMBL20120263 | 0.79 | APP (0.33) | CA12CA14EPHX2CA2 | |
| SCHEMBL166315 | 0.79 | CYP1A2 (0.44) | TSHRKMT2ALMNAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4456768-A | Chemical synthesis | THE UNIVERSITY OF CHICAGO (US) | 1984-06-26 | — | — | US | disclosed |
| US-4324730-A | Certain fluorine substituted PGI2 compounds | THE UNIVERSITY OF CHICAGO (US) | 1982-04-13 | — | — | US | disclosed |
| EP-0037422-A4 | FLUORO-SUBSTITUTED PROSTAGLANDINS AND PROSTACYCLINS. | UNIV CHICAGO (US) | 1982-01-26 | — | — | EP | disclosed |
| EP-0037422-A1 | FLUORO-SUBSTITUTED PROSTAGLANDINS AND PROSTACYCLINS | UNIVERSITY OF CHICAGO (US) | 1981-10-14 | — | — | EP | disclosed |
| WO-1981001002-A1 | FLUORO-SUBSTITUTED PROSTAGLANDINS AND PROSTACYCLINS | UNIV CHICAGO (US) | 1981-04-16 | — | — | WO | disclosed |