SCHEMBL11061657

SCHEMBL11061657

Cc1cc(Cl)nc(NC(=O)NS(=O)(=O)Cl)n1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.56
GAA P10253 1/20 0.50
CYP1A2 P05177 2/20 0.48
CASP1 P29466 1/20 0.48
ALOX15 P16050 1/20 0.44
MAPT P10636 2/20 0.44
ALDH1A1 P00352 1/20 0.41
TSHR P16473 1/20 0.41
LMNA P02545 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
S1PR2 O95136 1/20 0.39
POLB P06746 1/20 0.38
PCTP Q9UKL6 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10847775 0.91 GAA (0.58) KMT2AGAAALOX15MAPTALDH1A1
SCHEMBL10847825 0.81 GAA (0.53) GAACYP1A2ALOX15MAPTALDH1A1
SCHEMBL10848245 0.77 GAA (0.40) KMT2AGAAALOX15MAPTALDH1A1
SCHEMBL9948446 0.76 KMT2A (0.52) KMT2ACYP1A2CASP1MAPTLMNA
SCHEMBL13753804 0.76 GAA (0.60) KMT2AGAACYP1A2ALOX15MAPT
SCHEMBL31235463 0.76 KMT2A (0.55) KMT2ACYP1A2CASP1MAPTALDH1A1
SCHEMBL11005559 0.76 GAA (0.60) KMT2AGAACYP1A2ALOX15MAPT
SCHEMBL18037965 0.75 KMT2A (0.73) KMT2ACYP1A2CASP1MAPTALDH1A1
SCHEMBL18038045 0.75 KMT2A (0.78) KMT2ACYP1A2CASP1MAPTALDH1A1
SCHEMBL18037980 0.75 KMT2A (0.69) KMT2AGAACYP1A2CASP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4448959-A Chlorosulfonyl urea triazines CIBA-GEIGY CORPORATION (US) 1984-05-15 US disclosed
US-4391976-A Process for producing arylsulfamates CIBA-GEIGY CORPORATION (US) 1983-07-05 US disclosed