Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL409112 | 1.00 | TP53 (0.61) | TP53KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL6548558 | 1.00 | TP53 (0.61) | TP53KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL11409900 | 1.00 | TP53 (0.61) | TP53KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL6472994 | 1.00 | TP53 (0.61) | TP53KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL1868088 | 0.97 | — | — | |
| SCHEMBL4349330 | 0.92 | — | — | |
| Acetonitrile SCHEMBL27439464 | 0.87 | TP53 (0.48) | TP53KDM4ESMN1; SMN2GMNNLMNA | |
| SCHEMBL2246490 | 0.85 | — | — | |
| SCHEMBL1472491 | 0.85 | — | — | |
| SCHEMBL10882332 | 0.85 | TP53 (0.42) | TP53KDM4ESMN1; SMN2GMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0036741-B1 | PHOSPHINE COMPOUNDS, TRANSITION METAL COMPLEXES THEREOF AND USE THEREOF AS CHIRAL HYDROGENATION CATALYSTS | THE PROCTER & GAMBLE COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |
| US-4440936-A | Rhodium-phosphine chiral hydrogenation catalysis of acetophenone, atropic acid, and alpha-acylamidoacrylic acids and esters thereof | THE PROCTER & GAMBLE COMPANY (US) | 1984-04-03 | — | — | US | disclosed |
| US-4397787-A | STEREOSPECIFIC | THE PROCTER & GAMBLE COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4331818-A | 1,2-BIS(DIPHENYLPHOSPINO)-1-CYCLOHEXYLETHNE, RHODIUM COMPLEX IS HYROGENATION CATALYST FOR ACYLAMIDOACRYLIC ACIDS- | THE PROCTER & GAMBLE COMPANY (US) | 1982-05-25 | — | — | US | disclosed |
| EP-0036741-A2 | Phosphine compounds, transition metal complexes thereof and use thereof as chiral hydrogenation catalysts | THE PROCTER & GAMBLE COMPANY (US) | 1981-09-30 | — | — | EP | disclosed |