⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14997291 | 0.73 | — | — | |
| SCHEMBL20158793 | 0.73 | — | — | |
| SCHEMBL2376391 | 0.69 | — | — | |
| SCHEMBL3944987 | 0.69 | — | — | |
| SCHEMBL15172114 | 0.69 | — | — | |
| SCHEMBL3947301 | 0.69 | — | — | |
| SCHEMBL14559791 | 0.68 | — | — | |
| SCHEMBL25472223 | 0.67 | — | — | |
| SCHEMBL19943246 | 0.67 | — | — | |
| SCHEMBL576623 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446925-B1 | Process for the preparation of beta-resorcylic acid derivatives | CONSORTIUM ELEKTROCHEM IND (DE) | 1995-06-21 | — | — | EP | claimed |
| US-5171878-A | Reacting a diketene with a beta-keto ester in presence of alkaline earth compound; perfumes | CONSORTIUM FOR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 1992-12-15 | — | — | US | claimed |
| US-11744816-B2 | Fixed dose combinations and formulations comprising ETC1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease | ESPERION THERAPEUTICS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-20230210800-A1 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS INC (US) | 2023-07-06 | — | — | US | disclosed |
| US-20180133177-A1 | Treatment of NASH with Gemcabene | NEUROBO PHARMACEUTICALS, INC. | 2018-05-17 | — | — | US | disclosed |
| US-20180064671-A1 | Fixed Dose Combinations and Formulations Comprising ETC1002 and Ezetimibe and Methods of Treating or Reducing the Risk of Cardiovascular Disease | GLAS AMERICAS LLC | 2018-03-08 | — | — | US | disclosed |
| US-9855240-B2 | Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof | AMARIN PHARMACEUTICALS IRELAND LIMITED (IE) | 2018-01-02 | — | — | US | disclosed |
| US-9849104-B2 | Treatment of NASH with gemcabene | GEMPHIRE THERAPEUTICS INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20170349516-A1 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. | 2017-12-07 | — | — | US | disclosed |
| US-20170172955-A1 | Treatment of Mixed Dyslipidemia | NEUROBO PHARMACEUTICALS, INC. | 2017-06-22 | — | — | US | disclosed |
| US-20170172954-A1 | Treatment of NASH with Gemcabene | NEUROBO PHARMACEUTICALS, INC. | 2017-06-22 | — | — | US | disclosed |
| CN-101115488-B | Pharmaceutical use of atraric acid | LOHMANN THERAPIE SYST LTS | 2011-03-30 | — | — | CN | disclosed |
| US-20110003860-A1 | HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. | 2011-01-06 | — | — | US | disclosed |
| US-20090143466-A1 | Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2009-06-04 | — | — | US | disclosed |
| EP-1979309-A2 | PROCESS FOR THE PREPARATION OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONIC ACID AMIDES AND INTERMEDIATES USED THEREIN | Boehringer Ingelheim International GmbH (DE) | 2008-10-15 | — | — | EP | disclosed |
| US-7335689-B2 | for example, 6,9-Dihydroxy-2,2,13,13-tetramethyl-tetradecanedioic acid, 2,2,13,13-Tetramethyl-tetradecane-1,6,9,14-tetraol, 6,10-Dihydroxy-2,2,14,14-tetramethyl-pentadecanedioic acid; treatment of Alzheimer's Disease, metabolic syndrome disorder, cancer, cardiovascular disease, diabetic nephropathy | ESPERION THERAPEUTICS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| CN-101115488-A | Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the deritives thereof for the treatment of benign prostate hyperplasia, prostate carcinoma and spinobulbar | LOHMANN THERAPIE SYST LTS (DE) | 2008-01-30 | — | — | CN | disclosed |
| WO-2007084882-A2 | PROCESS FOR THE PREPARATION OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-A]IMIDAZOLE-3-SULFONIC ACID AMIDES AND INTERMEDIATES USED THEREIN | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-26 | — | — | WO | disclosed |
| US-20070173517-A1 | Synthesis of 6,7-Dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides | WIRTH THOMAS | 2007-07-26 | — | — | US | disclosed |
| US-5171878-A | Reacting a diketene with a beta-keto ester in presence of alkaline earth compound; perfumes | CONSORTIUM FOR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) | 1992-12-15 | — | — | US | disclosed |