Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067251 | 1.00 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11304241 | 0.81 | KDM4E (0.41) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11304246 | 0.76 | MEN1 (0.35) | KDM4EMEN1KMT2ASMN1; SMN2MAOB | |
| SCHEMBL11453865 | 0.73 | NPC1 (0.42) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL11454011 | 0.72 | NPC1 (0.34) | KDM4EMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL10966010 | 0.72 | KDM4E (0.51) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10966007 | 0.72 | KDM4E (0.51) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10966640 | 0.70 | KDM4E (0.49) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10966634 | 0.70 | KDM4E (0.49) | KDM4EMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL2186787 | 0.69 | KDM4E (1.00) | KDM4EMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4469633-A | N-oxides of 5-oxo-1-phenyl-2-benzazepines | HOFFMANN-LA ROCHE INC. (US) | 1984-09-04 | — | — | US | disclosed |
| US-4394311-A | Production of 2-benzazepines | HOFFMANN-LA ROCHE INC. (US) | 1983-07-19 | — | — | US | disclosed |
| US-4388239-A | Production of 1-halophenyl and 1-phenyl-3,4-dihydro-5H-2-benzazepine-5-ones | HOFFMANN-LA ROCHE INC. (US) | 1983-06-14 | — | — | US | disclosed |
| US-4379090-A | Process for the preparation of 1-(phenyl and halophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]5H-2-benzazepin-5-one-2-oxides | HOFFMANN-LA ROCHE INC. (US) | 1983-04-05 | — | — | US | disclosed |
| EP-0014454-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 2-BENZAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-22 | — | — | EP | disclosed |
| US-4318854-A | Intermediates in the production of 2-benzazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-03-09 | — | — | US | disclosed |
| EP-0014454-A2 | Process and intermediates for the preparation of 2-benzazepine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-08-20 | — | — | EP | disclosed |