Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069255 | 1.00 | MAPT (0.41) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11071819 | 1.00 | MAPT (0.41) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11071814 | 1.00 | MAPT (0.41) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11074551 | 0.98 | CYP2C9 (0.42) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11073252 | 0.98 | CYP2C9 (0.42) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11074553 | 0.98 | CYP2C9 (0.42) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11074138 | 0.98 | CYP2C9 (0.42) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11066966 | 0.97 | MAPT (0.43) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL11069213 | 0.97 | MAPT (0.43) | MAPTGAACYP2C9MEN1KMT2A | |
| SCHEMBL10342830 | 0.96 | MAPT (0.39) | MAPTGAACYP2C9MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4462923-A | Disubstituted pyrimidines | HOFFMANN-LA ROCHE INC. (US) | 1984-07-31 | — | — | US | disclosed |