Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 3/20 | 0.39 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | SELE | P16581 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10956424 | 0.89 | HSD17B10 (0.33) | — | |
| SCHEMBL11066111 | 0.81 | HSD17B10 (0.36) | PARP10 | |
| SCHEMBL11062436 | 0.81 | HSD17B10 (0.33) | — | |
| SCHEMBL11055926 | 0.78 | SMN1; SMN2 (0.35) | MAP3K7TAB1GSK3BKDM4EALDH1A1 | |
| SCHEMBL11063674 | 0.77 | CYP3A4 (0.38) | MAP3K7TAB1KDM4EALDH1A1 | |
| SCHEMBL11058625 | 0.74 | MAP3K7 (0.36) | MAP3K7TAB1PARP10GSK3B | |
| SCHEMBL10959917 | 0.74 | PARP10 (0.35) | MAP3K7TAB1PARP10KDM4EALDH1A1 | |
| SCHEMBL11055963 | 0.73 | POLB (0.30) | — | |
| SCHEMBL11061057 | 0.71 | MAP3K7 (0.37) | MAP3K7TAB1GSK3BKDM4EALDH1A1 | |
| SCHEMBL10957826 | 0.70 | POLB (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4434167-A | Pyrimidyl thioureas useful for the treatment of hypertension and hyperlipidemia | BEIERSDORF AKTIENGESELLSCHAFT (DE) | 1984-02-28 | — | — | US | disclosed |