SCHEMBL11069880

SCHEMBL11069880

COC(=O)COc1ccc(Cl)cc1Cc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGER1 P34995 10/20 0.54
MAPT P10636 2/20 0.51
PTGDR2 Q9Y5Y4 3/20 0.51
PTGDR Q13258 2/20 0.51
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
TSHR P16473 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
CYP3A4 P08684 1/20 0.49
HPGD P15428 1/20 0.49
ALOX15 P16050 1/20 0.49
HIF1A Q16665 1/20 0.49
HSD17B10 Q99714 1/20 0.49
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4656398 0.89 PTGER1 (0.52) PTGER1PTGDR2PTGDR
SCHEMBL4627361 0.89 PTGDR (0.58) MAPTPTGDR2PTGDRTSHRTDP1
SCHEMBL4627039 0.88 PTGDR2 (0.52) MAPTPTGDR2PTGDRMEN1KMT2A
SCHEMBL4626978 0.86 MAPT (0.65) MAPTPTGDR2PTGDRTSHRTDP1
SCHEMBL3968621 0.86 PTGER1 (0.56) PTGER1MAPTPTGDR2PTGDRMEN1
SCHEMBL2942929 0.85 PTGDR2 (0.49) PTGER1MAPTPTGDR2PTGDRMEN1
SCHEMBL5000568 0.84 PTGDR2 (0.47) PTGER1MAPTPTGDR2PTGDRMEN1
SCHEMBL2945278 0.82 MAPT (0.70) MAPTPTGDR2PTGDRTSHRTDP1
SCHEMBL4626196 0.81 MAPT (0.55) PTGER1MAPTMEN1KMT2ATDP1
SCHEMBL2944675 0.81 PTGDR (0.55) MAPTPTGDR2PTGDRTSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4483999-A Phenoxy alkanoic acid derivatives having the ability to lower the level of fatty substances in the blood SIEGFRIED AKTIENGESELLSCHAFT (CH) 1984-11-20 US disclosed